TET3 inhibits TGF-β1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells
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UBE2T silencing inhibits TGF-β1-induced epithelial-to-mesenchymal transition in colon cancer cells
Epithelial-mesenchymal transition (EMT) is considered as the first and key step for the migration and invasion of cancers including colon cancer. Ubiquitin-conjugating enzyme E2T (UBE2T), a member of the E2 family, plays an important role in tumorigenesis and progression. However, its role in colon cancer has not been investigated. In this study, we investigated the effect of UBE2T on transform...
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BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by the accumulation of excessive fibroblasts and myofibroblasts in the extracellular matrix. The transforming growth factor β1 (TGF-β1)-induced epithelial-to-mesenchymal transition (EMT) is thought to be a possible source of fibroblasts/myofibroblasts in IPF lungs. We have previously reported t...
متن کاملAdenovirus-mediated P311 inhibits TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells via TGF-β1-Smad-ILK pathway.
P311, a highly conserved 8-kDa intracellular protein, has been indicated as an important factor in myofibroblast transformation and in the progression of fibrosis. In the present study, we constructed a recombinant adenovirus vector of p311 (called Ad-P311) and transferred it into rat renal proximal tubular epithelial cells (NRK-52E) to explore the effect of P311 on epithelial-mesenchymal trans...
متن کاملTrichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium
BACKGROUND AND OBJECTIVES Tissue remodeling is believed to cause recalcitrant chronic rhinosinusitis (CRS). Epithelial-mesenchymal transition (EMT) is a novel clinical therapeutic target in many chronic airway diseases related with tissue remodeling. The aim of this study was to investigate the effect of trichostatin A (TSA) on transforming growth factor (TGF)-β1-induced EMT in airway epitheliu...
متن کاملBortezomib inhibits proliferation, migration, and TGF-β1–induced epithelial–mesenchymal transition of RPE cells
Purpose Nuclear factor kappa B (NF-κB) plays an important role in the epithelial-mesenchymal transition (EMT) of RPE cells. We investigated the effects of a proteasome inhibitor, bortezomib, on the EMT in RPE cells. In addition, we assessed the influence of bortezomib on regulation of the NF-κB pathway during this process. Methods After treatment with various concentrations of bortezomib, cel...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2016
ISSN: 1756-9966
DOI: 10.1186/s13046-016-0350-y